Effective dosing of L-carnitine in the secondary prevention of cardiovascular disease: a systematic review and meta-analysis
نویسندگان
چکیده
BACKGROUND L-carnitine supplementation has been associated with a significant reduction in all-cause mortality, ventricular arrhythmia, and angina in the setting of acute myocardial infarction (MI). However, on account of strict homeostatic regulation of plasma L-carnitine concentrations, higher doses of L-carnitine supplementation may not provide additional therapeutic benefits. This study aims to evaluate the effects of various oral maintenance dosages of L-carnitine on all-cause mortality and cardiovascular morbidities in the setting of acute MI. METHODS After a systematic review of several major electronic databases (PubMed, EMBASE, and the Cochrane Library) up to November 2013, a meta-analysis of five controlled trials (n = 3108) was conducted to determine the effects of L-carnitine on all-cause mortality and cardiovascular morbidities in the setting of acute MI. RESULTS The interaction test yielded no significant differences between the effects of the four daily oral maintenance dosages of L-carnitine (i.e., 2 g, 3 g, 4 g, and 6 g) on all-cause mortality (risk ratio [RR] = 0.77, 95% CI [0.57-1.03], P = 0.08) with a statistically insignificant trend favoring the 3 g dose (RR = 0.48) over the lower 2 g dose (RR = 0.62), which was favored over the higher 4 g and 6 g doses (RR = 0.78, 0.78). There was no significant differences between the effects of the daily oral maintenance dosages of 2 g and 6 g on heart failure (RR = 0.53, 95% CI [0.25-1.13], P = 0.10), unstable angina (RR = 0.90, 95% CI [0.51-1.58], P = 0.71), or myocardial reinfarction (RR = 0.74, 95% CI [0.30-1.80], P = 0.50). CONCLUSIONS There appears to be no significant marginal benefit in terms of all-cause mortality, heart failure, unstable angina, or myocardial reinfarction in the setting of acute MI for oral L-carnitine maintenance doses of greater or less than 3 g per day.
منابع مشابه
Author's response to reviews Title:Effective Dosing of L-Carnitine in the Secondary Prevention of Cardiovascular Disease: a Systematic Review and Meta-Analysis Authors:
متن کامل
L-carnitine in the secondary prevention of cardiovascular disease: systematic review and meta-analysis.
OBJECTIVE To evaluate the effects of L-carnitine compared with placebo or control on morbidity and mortality in the setting of acute myocardial infarction. METHODS A systematic review and meta-analysis of 13 controlled trials (N=3629) was conducted to determine the effects of L-carnitine vs placebo or control on mortality, ventricular arrhythmias (VAs), angina, heart failure, and reinfarction...
متن کاملPrevalence of Comorbidities in COVID-19 Patients: A Systematic Review and Meta-Analysis
Background: In this study, we aimed to assess the prevalence of comorbidities in the confirmed COVID-19 patients. Thismight help showing which comorbidity might pose the patients at risk of more severe symptoms.Methods: We searched all relevant databases on April 7th, 2020 using the keywords (“novel coronavirus” OR COVID-19OR SARS-CoV-2 OR Coronavirus) AND (comorbidities OR cl...
متن کاملNutraceuticals in Hyperlipidemic Children: a Systematic Review and Meta-analysis
Background Dyslipidemia is a major risk for cardiovascular diseases. The aim of this study is to review the effects of nutraceuticals to modify lipid disorders in children. Materials and Methods The literature research was conducted in EMBASE, Medline, PubMed, Scopus, ISI Web of Science, and Cochrane library from 2002 until January 2015. The following keywords were used: dyslipidemia, hyperlipi...
متن کاملCardiovascular Effects of Olive, a Qur’anic Fruit: a Systematic Review
Background and Objective: Today, much attention is being paid to the prevention of cardiovascular diseases. In some parts of the world, the rate of cardiovascular disease is low due to a Mediterranean diet containing olive oil. This systematic review examined the verses and traditions in order to express opinions on olive and compare it with the findings of modern medicine. Methods: This is ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
دوره 14 شماره
صفحات -
تاریخ انتشار 2014